Meta-analysis on relationship between ApoB gene XbaI polymorphism and cerebral infarction in Chinese population
- VernacularTitle:中国人群载脂蛋白B基因XbaI多态性与脑梗死关系的Meta分析
- Author:
Shuo ZHANG
;
Yang GUO
;
Yan MA
- Publication Type:Journal Article
- Keywords:
ApoB;
cerebral infarction;
polymorphism;
Meta-analysis
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The relationship between XbaI polymorphism of ApoB gene and cerebral infarction(CI)among Chinese population was assessed by Meta-analysis.Methods All related case-control studies were collected from all publications,the relevant studies were identified after eliminating those poor-qualified studies.Meta-analysis was conducted for investigating heterogeneity among individual studies,and summarizing the effects across studies.Results The combined data statistics revealed the frequencies of the X-X+/X+X+ genotypes showed no statistically difference(Z=1.72,P=0.08).Through the subgroup analysis,it was obviously increase the risk of CI in Chinese northern population(OR=2.66,95%CI:1.67~4.24),but no statistically difference in Chinese southern population(OR=1.26,95%CI:0.90~1.77).Conclusions ApoB gene XbaI polymorphism may be significantly associated with susceptibility of CI in Chinese northern population,but not a definite risk for Chinese southern population.
