Experimental study of acute toxicity of slow-release PLGA-gemcitabine microsphere
10.3760/cma.j.issn.1006-9801.2012.09.010
- VernacularTitle:吉西他滨缓释微球急性毒性实验研究
- Author:
Jingquan LI
;
Shiliang WANG
;
Manzhi DING
;
Dianliang CHEN
;
Mudan ZHU
;
Yongdong PU
- Publication Type:Journal Article
- Keywords:
Neoplasms,experimental;
Gemcitabine;
Slow-release;
Microsphere;
Acute toxicity;
Lethal dose 50
- From:
Cancer Research and Clinic
2012;24(9):610-612,619
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the acute toxicity of slow-release (poly lactic-co-glycolic acid) PLGA-gemcitabine microsphere and gemcitabine on mice.Methods Up and down procedure (UDP) was used to determine the median lethal dose (LD50) of PLGA-gemcitabine microsphere and gemcitabine on mice respectively.Results The LD50 of PLGA-gemcitabine microsphere on mice was 256.30 mg/kg,gemcitabine was 8.91 mg/kg.The difference was 28.8 times.Conclusion PLGA-gemcitabine microsphere can markedly reduce the acute toxicity of gemcitabine.
