Transgelin expression in prognosis of hepatocellular carcinoma after hepatectomy
10.3760/cma.j.issn.1673-4203.2011.04.003
- VernacularTitle:微管蛋白Transgelin判断肝癌切除术预后的临床价值探讨
- Author:
Jigang QIU
;
Yongqiang WENG
;
Jianxiong TANG
;
Zurong YUAN
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Transgelin;
Tissue microarray;
Biomarker
- From:
International Journal of Surgery
2011;38(4):221-225,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical meaning of Transgelin expression in heptacellular carcinoma(HCC) in prognosing recurrence after hepatectomy. Methods The expression of Transgelin in cancerous lesions and tissue adjacent to cancer lesions from 223 operation samples was detected by immunohistochemical staining combined with tissue microarray techniques. The correlation between the level of Transgelin expression and the prognosis was analyzed by means of log- rank test, Kaplan- Meier analysis and multivariate Cox regression analysis. Results Transgelin was higher expressed in tumor tissue than in tissue adjacent to cancer lesions. Transgelin was positively correlated with the presence of tumor size, portal vein invasion, pTNM tumor stages and serum AFP level. Patients with positive expression of Transgelin had worse tumor free survival than those with negative ones (P ＜0. 01). The multivariate Cox regression analysis showed that Transgelin expression level was one of the independent prognostic factors in tumor free survival after surgery. Conclusions The expression of Transgelin in hepatocellular carcinoma was significantly associated with recurrence in patients with HCC after hepatectomy, and this protein could be the biomarker of the prognosis in HCC surgery.
