Granulocyte-macrophage colony-stimulating factor down-regulates rat thyroid C cells
- VernacularTitle:粒细胞-巨噬细胞集落刺激因子对大鼠甲状腺C细胞数量的影响
- Author:
Yongli ZHANG
;
Guangrong DAI
;
Bingyin SHI
- Publication Type:Journal Article
- Keywords:
Granulocyte-macrophage colony-stimulating factor;
C cell;
Calcitonin;
Immunohistochemistry
- From:
Journal of Medical Postgraduates
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of the granulocyte-macrophage colony-stimulating factor(GM-CSF) on rat thyroid parafollicular cells(C cells).Methods: A total of 48 healthy SD rats were randomly and equally divided into a control group,a low dose group(GM-CSF 10 ?g/kg?d-1) and a high dose group(GM-CSF 50 ?g/kg?d-1).The latter two groups were treated by intraperitoneal administration of GM-CSF at their respective doses for 7 days,and then the thyroid parafollicular cells were stained by immunohishtochemical streptavidin-peroxidase(S-P) technique and their number counted.Results: The number of C cells was(67.43 ? 13.73)in the high dose group,significantly smaller than that of the low dose group(85.97 ? 20.12)(P
