Effect of Three Traditional Chinese Medicine Compounds on Level of Expression of Caspase 3 of Spleen in Sepsis Rats
- VernacularTitle:3种中药对脓毒症大鼠脾脏半胱天冬酶3表达影响的对比研究
- Author:
Chengdong SUN
;
Shuwen ZHANG
;
Zhen LI
;
Yan WEN
;
Chenghong YIN
;
Baoen WANG
- Publication Type:Journal Article
- Keywords:
Sepsis;
Qingregranules compound;
Qishenghuoxue granules;
Tongfu granules;
Caspase 3
- From:
Chinese Journal of Nosocomiology
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the characteristic change of the expression of caspase 3 of spleen in different sepsis rats.METHODS We designed sepsis model by cecal ligation puncture,divided into five groups,sampled tissue in 3,24 and 72 h after model built,and compared the change between groups.We employed the immuno-histochemistry to examine the positive expression of caspase 3 in spleen,and examined the index of apoptosis in different groups.RESULTS The result showed that three traditional Chinese medicine compounds could significantly cut down the expression of caspase 3 in spleen lymphocyte.CONCLUSIONS The three traditional Chinese medicine compounds could decrease the apoptosis of lymphocyte,and adjust the immunity.
