Antibacterial Activity of Allicin Combined with Cefoperazone Against Pseudomonas aeruginosa
- VernacularTitle:大蒜素与头孢哌酮联用对铜绿假单胞菌的药敏研究
- Author:
Yun CAI
;
Shuxin NI
;
Fei PEI
;
Yanjun ZHENG
;
Beibei LIANG
;
Yan FAN
;
Congran LI
;
Weihang TONG
;
Rui WANG
- Publication Type:Journal Article
- Keywords:
Allicin;
Cefoperazone;
Pseudomonas aeruginosa;
FIC index
- From:
Chinese Journal of Nosocomiology
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the in virto interaction of allicin combined with cefoperazone against clinical isolates of Pseudomonas aeruginosa.METHODS The protocol was designed by checkerboard method and the MICs of allicin combined with cefoperazone against the 17 strains of sensitive and 14 strains of drug-resistant P.aeruginosa were determined by broth dilution method,the FIC index was calculated according to MIC results.The combined effects were confirmed by FIC index.RESULTS The percentage of the FIC index less than 0.5,from 0.5 to 1,from 1 to 2,and more than 2 was 41.2-64.3% 35.7-41.2% 0-17.6%,and 0%,respectively.CONCLUSIONS Synergism and additivity of allicin combined with cefoperazone against P.aeruginosa are their main action,there are little autonomy and no antagonism.Allicin can significantly improve the antibacterial activity of cefoperazone against drug-resistant P.aeruginosa.
