Relationship among Hepatitis B Virus Basic Core Promoter Mutation and Serum HBV DNA Contents and HBV Markers as well as Liver Function
- VernacularTitle:乙型肝炎病毒核心基因启动子变异与患者血清病毒载量和标志物及肝功能的关系
- Author:
Liyi HUANG
;
Lisheng ZHANG
;
Yanhong YU
;
Jizhou WU
;
Lu HUANG
- Publication Type:Journal Article
- Keywords:
HBV BCP;
Gene mutation;
HBV DNA;
HBV markers;
Liver function
- From:
Chinese Journal of Nosocomiology
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the relationship among hepatitis B virus(HBV) basic core promoter(BCP) mutation,serum HBV DNA contents and HBV markers as well as liver function of chronic hepatitis B patients.METHODS The A to T mutation at nucleotide 1762 and G to A mutation at nucleotide 1764 were determined by the method of polymerase chain reaction(PCR) microplate hybridization ELISA in 176 patients with chronic hepatitis B virus infection.RESULTS The rate of HBV BCP mutants in negative and positive groups of HBeAg was 49.4% and 33.3%,respectively(P
