Relationship Between Change in Tolllike Receptor Expression and Prognosis of Severe Viral Hapatitis
- VernacularTitle:重型病毒性肝炎患者外周血单个核细胞Toll样受体基因表达变化与预后关系的研究
- Author:
Min DENG
;
Xiaofei CHEN
- Publication Type:Journal Article
- Keywords:
Toll-like receptor;
Endotoxins;
Hepatitis
- From:
Chinese Journal of Nosocomiology
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the relationship between the change in Toll-like receptor expression and prognosis of severe viral hapatitsis.METHODS The peripheral blood mononuclear cells were separated and the expression of TLR2 and TLR4 mRNA was observed by reverse transcription-polymerase chain reaction(RT-PCR).The level of serum endotoxin was measured by chromogenic substrate Limulus amebocyte lysate assay.The data were analyzed by SPSS 11.5 software.RESULTS The expression of TLR2 and TLR4 mRNA and the level of serum endotoxin of death group before therapy were lightly higher than that of survival group,but after therapy that of death group is higher than survival group(P
