Progress in The Study of Novel Tumor Suppressor of ING Family
- VernacularTitle:生长抑制因子(ING)抑癌基因家族的研究进展
- Author:
Jing NIE
;
Chunyan TIAN
;
Fuchu HE
- Publication Type:Journal Article
- Keywords:
ING, PHD finger, tumor suppressor, epigenetic regulation, phosphatidy Linosital (PtdInsPs)
- From:
Progress in Biochemistry and Biophysics
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Inhibitor of growth (ING) family proteins belong to candidate tumor suppressor proteins. The ING proteins participate in PtdInsPs-mediated lipid signaling and hormone signaling pathways. They are associated with histone acetyltransferase, histone deacetylase and play a role in chromatin remodeling and gene transcription regulation. ING proteins regulate cell growth, apoptosis and DNA damage repair in p53 dependent manner; thus linking the processes of cell cycle regulation, apoptosis and cellular aging through epigenetic regulation of gene expression.
