Relationship among Toxicity Gene Type,vacA Gene Subtypes of Hp and Hp-related Upper Gastrointestinal Diseases
- VernacularTitle:幽门螺杆菌的毒力基因、vacA基因亚型与上消化道疾病关系的研究
- Author:
Fenqun CAO
;
Jf CHENG
;
Haibin CHE
;
Yonghua CHEN
;
Haifeng MA
;
Zhaohui YU
;
Youming LI
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Molecular typing;
Gastrointestinal diseases
- From:
Chinese Journal of Nosocomiology
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To assess the relationship among the genes types ureA,cagA,vacA,gene vacA subtypes and Helicobacter pylori(Hp)-related upper gastrointestinal diseases in this study.METHODS Eighty-four Hp strains were identified from bacteria isolated and cultured from the gastric mucosa tissue.Genes ureA,cagA,vacA,and gene vacA subtypes were typed using PCR with specific primers.RESULTS In 84 identified Hp strains,the positive ratio of gene ureA was 100.00%,of gene cagA was 90.48%,and of gene vacA was 95.24%.The positive ratio of genes cagA and vacA was lower in gastric cancer than in gastritis and peptic ulcer(P0.05).CONCLUSIONS ure+,cagA+ and vacAm2 subtypes of Hp are predominant in patients with upper gastrointestinal diseases in Zhenhai District,Ningbo,Zhejiang Province.They are more common in patients with gastric ulcer and gastritis.
