Protective effect of short-term exercise on ischemic/reperfused myocardium in rats
- VernacularTitle:短期运动对大鼠缺血/再灌注心肌的保护作用
- Author:
Yunying HOU
;
Xiuzhen FAN
;
Zhiyong MA
- Publication Type:Journal Article
- Keywords:
exercise;
ischemia/reperfusion;
myocardioprotection;
protein kinase C
- From:
Basic & Clinical Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of short-term moderate exercise on ischemic/reperfused myocardium and its correlation to the activation of protein kinase C(PKC).Methods Fourty Wistar rats were randomly divided into 4 groups(n=10 respectively): control group(CON group),exercise group(EXE group),exercise + PKC inhibitor group(E+C group) and PKC inhibitor group(CHE group).The occurrence of arrhythmia,the recovery of cardiac function,and infarct size were observed by using the Langendorff-ischemia/reperfusion model in isolated rat heart in vitro.Results Recovery rate of LVDP(on the 30th and 60th minute of reperfusion) and RPP(on the 20th,30th and 60 minute of reperfusion) of EXE group were higher than those of CON and E+C groups(P
