Th17 cell and CD4 + CD25 + Treg in iathogenesis of asthma
10.3760/cma.j.issn.1673-4408.2012.02.026
- VernacularTitle:Th17细胞与Treg细胞在支气管哮喘发病机制中的研究进展
- Author:
Bin YAO
- Publication Type:Journal Article
- Keywords:
Th17 cells;
CD4+CD25+regulatory T cell;
Asthma
- From:
International Journal of Pediatrics
2012;39(2):196-198,202
- CountryChina
- Language:Chinese
-
Abstract:
Many studies have suggested that pathogenesis of asthma could no longer be interpreted merely by “Th1/Th2 balance” theory.CD4 + CD25 + Treg and Th17 cells,as well as their cytokines such as IL-10,transforming growth factor-β,and IL-17,account for asthma.CD4 + CD25 + Treg and Th17 are functionally antagonistic to each other,and also go with each other during their differentiation.Therefore,immunity-unbalance of CD4 + CD25 + Treg and Th17 is one of the most important factors that triggers asthma.Glucocorticoid has been shown to down regulate IL-17 expression by retinoic acid receptors γt signaling pathway,and regulate differentiation and function of CD4 + CD25 + Treg by inducing expression of transcription factor Foxp3,all of these are immuno-mechanisms of glucocorticoid in asthma treatment.
