Inhibitory effect of antigliomatin on expression of VEGF in rat C6 brain glioma cells
- VernacularTitle:抑胶素对大鼠C6胶质瘤细胞血管内皮生长因子的抑制作用
- Author:
Li CUI
;
Weihong LIN
;
Yi YANG
;
Dan XU
;
Shao WANG
;
Shuqin ZHANG
- Publication Type:Journal Article
- Keywords:
antigliomatin;
glioma;
endothelial growth factor
- From:
Journal of Jilin University(Medicine Edition)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the inhibitory effect of antigliomatin on the expression of vascular endothelial growth factor(VEGF) in rat C6 brain glioma cells.Methods The rat brain glioma cells was cultivated with the stationary culture technique.The different rat C6 brain glioma cells groups were treated with 2,4,8,and 16 ng?L-1 antigliomatin for 72 h in vitro and then the inhibitory effect of antiglioma on the expression of VEGF was observed with immunohistochemical method.Results The cytoplasm and(or) nucleus of most VEGF positive cells were stained to yellow brown.VEGF expressed significantly in cytoplasm of the rat C6 glioma cells in control group.The density of the VEGF positive cells was decreased in glioma compared with control group after treated with antigliomatin for 72 h(P
