Expressions of Bcl-2 and Bax protein in cochlea of diabetic rats
- VernacularTitle:Bcl-2和Bax蛋白在糖尿病大鼠耳蜗中的表达
- Author:
Bo DU
;
Ping WANG
;
Yusheng WANG
;
Baodong DU
- Publication Type:Journal Article
- Keywords:
Bcl-2 protein;
Bax protein;
diabetes mellitus,experimental;
cochlea
- From:
Journal of Jilin University(Medicine Edition)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of cochlear injury and expressions of Bcl-2 and Bax in the cochlea of diabetic rats.Methods Thirty five Wistar rats were randomly divided into diabetic group(n=25) and control group(n=10).Diabetic deafness was induced in rats by intraperitoneal injection of streptozotocin,while the rats in normal group were injected with normal saline.Immunohistochemical staining was used to detect the protein levels of Bcl-2 and Bax in the cochlea after 3 months.Results No significantly morphological change in cochlea of diabetic rats was found.The Bcl-2 levels in stria vascularis in diabetic group and control group were 135.32?21.69 and 45.32?9.08,respectively,there was significant difference(P
