Puerarin ameliorates oxidative stress in patients undergoing continuous ambulatory peritoneal dialysis
- VernacularTitle:腹膜透析液添加葛根素对氧化应激状态的影响
- Author:
Cheng SUN
;
Miao ZHANG
;
Chunming JIANG
- Publication Type:Journal Article
- Keywords:
Puerarin;
Peritoneal dialysis;
Oxidative stress
- From:
Journal of Medical Postgraduates
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the impact of Puerarin on oxidative stress in patients undergoing continuous ambulatory peritoneal dialysis(CAPD).Methods: Thirty-eight patients CAPD were randomly divided into two groups,an experimental group(n=19) receiving peritoneal dialysis fluid containing Puerarin(50 mg/2L) in vivo for two weeks and a control group(n=19) receiving dialysis fluid without Puerarin.The concentrations of oxidative stress markers in the serum and effluent such as glutathione(GSH),total-superoxide dismutase(T-SOD),malondialdehyde(MDA),Kt/V and creatinine clearance rate of the two groups(Ccr) were measured and compared before and after the treatment.Results: After the treatment,the concentrations of GSH and T-SOD in the serum and effluent were significantly higher(P
