Significance of detection of the autoantibodies in patients with rheumatoid Arthritis
10.3760/cma.j.issn.1008-1372.2011.04.014
- VernacularTitle:类风湿关节炎相关抗体测定及其临床实用性的研究
- Author:
Jing GUO
;
Jing HE
;
Ru LI
;
Tian LIU
;
Xia LIU
;
Yongfu WANG
;
Zhanguo LI
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid/IM;
Antibodies/ME;
Immunoglobulin M/ME;
Rheumatoid factor/ME;
Keratins/ME
- From:
Journal of Chinese Physician
2011;13(4):477-479,483
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the sensitivity of antibodies against RF,APF,AKA,anti-CCP in rheumatoid arthritis (RA) and analyze the relationship between these autoantibodies in RA.MethodsFive hundreds of RA patients were studied.Immunoturbidmetry was used to measure the RF-IgM.The enzyme-linked immunosorbent assay (ELISA) was used to measure the HRF-IgG,HRF-IgA and anti-CCP.Indirect immunofluorescence was used to measure the APF and AKA.ResultsThe seropositive rates of RF-IgM,anti-CCP,APF,HRF-IgG,AKA and HRF-IgA were 78.0%,70.8%,51.8%,48.4%,45.0% and 20.0% respectively.RF-IgM could not be detected in 110 patients while the seropositive rates of anti-CCP,APF,AKA,HRF-IgG and HRF-IgA were 41.8%,27.3%,22.7%,15.5% and 1.8% respectively.Anti-CCP could not be detected in 146 patients while the seropositive rates of RF-IgM,HRF-IgG,APF,AKA and HRF-IgA were 56.8%,24.7%,16.4%,8.9% and 7.5% respectively.The combined sensitivities of RF-IgM anti-CCP and APF were higher than others.The seropositive rates were 88.6%.ConclusionsRF-IgM and anti-CCP are sensitive antibodies for diagnosis of RA.Combinations RF-IgM with anti-CCP can significantly improve the sensitivity of diagnosis of RA.
