Rhodiola decreases the expression of ?-smooth muscle actin in tuhulointerstitial of adriamycin-induced nephropathy rats
- VernacularTitle:红景天抑制阿霉素肾病大鼠肾小管间质?平滑肌肌动蛋白表达
- Author:
Wenjuan ZHANG
;
Yongbin SHI
;
Weifeng XU
- Publication Type:Journal Article
- Keywords:
adriamycin-induced nephropathy;
rhodiola herb;
?-smooth muscle actin;
myofibroblast
- From:
Basic & Clinical Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find the effect of Rhodiola herb on the phenotypic transfer of epithelial cell in renal tubule of adriamycin-induced nephropathy rats.Methods The rat nephropathy model is established by adriamycin.For Rhodiola herb treated group,feed with Rhodiola herb 0.672 g/kg?d from the 4th week,for the control group and neohropathy group,feed with water [3 mL/(kg?d)].Kill the rats per batch at the week of 4th,8th,12th,16thand 20th week,observe the pathological change of nephridial tissue,test the expression of ?-SMA-protein of myofibroblast in the tuhulointerstitial.Results A semi-quantitative analysis of ?-SMA of rats at the 16th week in the nephropathy group is 6.24?0.57,which is obviously higher than that of Rhodiola herb treated group,3.84?0.28(P
