Improved technology of inducing dilated cardiomyopathy animal model of rats by peritoneally injecting adriamycin
- VernacularTitle:腹腔注射阿霉素建立扩张型心肌病大鼠模型的方法学改进
- Author:
Guoqiang ZHONG
;
Guotian MA
;
Tangwei LIU
;
Yan LI
;
Weiming WEN
;
Xianghon WU
- Publication Type:Journal Article
- Keywords:
adriamycin;
rats;
dilated cardiomyopathy;
animal model
- From:
Basic & Clinical Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop rats model for human dilated cardiomyopathy(DCM).Methods Male Sprague-Dawley rats were administered adriamycin intraperitoneally 2.8 mg/kg? week)for 11 weeks,and then observed for 2 weeks.Plasma levels of brain natriuretic peptide(BNP)were studied by ELISA;left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD)and left ventricular ejection fraction(LVEF)were measured by echocardiogram;and morphology of the hearts and pathological lesions of cardiac muscle tissues were observed.Results(1)The levels of BNP of the DCM group were higher than those of the normal group(P
