Correlation of P53 expression with proliferation and apoptosis in gestational trophoblastic tumor
- VernacularTitle:P53与妊娠滋养细胞肿瘤的增殖和凋亡
- Author:
Jiangong HU
;
Yazhou AO
;
Zhaohui XIE
;
Ligang SONG
;
Ning WANG
;
Xuefeng DONG
;
Xianghong ZHANG
- Publication Type:Journal Article
- Keywords:
gestational trophoblastic tumor;
P53;
proliferation;
apoptosis;
immunohistochemistry;
TUNEL
- From:
Basic & Clinical Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the features of the expression of P53,proliferation and apoptosis in gestational trophoblastic tumor(GTT).Methods Ten cases of normal placenta,10 cases of complete hydatidiform mole(CM),20 cases of invasive hydatidiform mole(IM)and 19 cases of choriocarcinoma(CCA)paraffin-embedded tissues were studied.P53 and PCNA were detected with immunohistochemistry,apoptosis was detected with terminal deoxy-nucleotidyl transferase-mediated dUTP-biotin nick end labeling(TUNEL).Results In NP,CM,IM and CCA,the P53 indexes(P53-Ⅰ)were 4.12%,21.68%,39.61% and 27.39% respectively with significant differences among them(P
