Study of relationship between polymorphisms of apolipoprotein E gene and patients with hepatitis C virus infection
- VernacularTitle:载脂蛋白E基因分型与HCV感染的相关性分析
- Author:
Wei WANG
;
Qingfeng MA
;
Wen YAO
;
Xiaochun MIN
- Publication Type:Journal Article
- Keywords:
apolipoprotein E;
gene polymorphism;
hepatitis C virus;
serum lipid
- From:
Chinese Journal of Clinical Laboratory Science
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between polymorphisms of apolipoprotein E (apoE) and hepatitis C virus (HCV) infection.Methods The multiplex amplification refractory mutation system polymerase chain reaction (multi-ARMS PCR) technique was used to analyze apoE genotype of 186 patients with HCV infection and 108 healthy controls. Serum lipid level was also determined. The results were processed by statistical analysis.Results The serum levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol ( LDL-C) and apolipoproteinB (apoB) in patients group were significantly lower than those in healthy control group (P
