Inhibitions of daidzein on intima proliferation of rat common carotid artery injured by balloon
- VernacularTitle:大豆苷元对大鼠颈总动脉球囊损伤后内膜增殖的抑制作用
- Author:
Haiyan SUN
;
Shuzheng LU
;
Shu LIU
- Publication Type:Journal Article
- Keywords:
Isoflavones;
Tunica intima;
Cell proliferation
- From:
Chinese Journal of Interventional Cardiology
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of daidzein on intima proliferation of rat common carotid artery injured by balloon. Methods 24 male Wistar rats were randomly assigned to 3 groups, 8 rats per group: high dose daidzein group (100 mg/kg?d), low dose daidzein group (50 mg/kg?d) and dissolvent control group. Duplicate the rat common carotid arteries injured by balloon models. Five weeks after operation, serum biochemical indicator such as TC, TG, BUN, ALT and MDA were measured using routine biochemical methods. And pathological sections of common carotid arteries were observed and the changes of vascular histomorphology were estimated by computer analysis of photomicrograms. Results Compared with control group, the intima areas was significant decreased in high dose group and low dose group (86 893?83 452 ?m2 vs 199 419?103 352 ?m2 vs 222 324?56 154 ?m2,P0.05). Conclusion Daidzein can inhibit the intima proliferation of Wistar rat common carotid arteries injured by balloon.
