Changes of different regulators of G protein signaling in spontaneously hypertensive rat
- VernacularTitle:自发性高血压大鼠不同G蛋白信号调节因子的变化
- Author:
Yuyan WANG
;
Jialin SU
;
Yuanjie MAO
- Publication Type:Journal Article
- Keywords:
Hypertension;
GTP-binding protein regulators;
Rats,inbred SHR
- From:
Chinese Journal of Interventional Cardiology
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study changes of different regulators of G protein signaling(RGS) including RGS2, RGS3 and RGS4 mRNA in aorta and heart of spontaneously hypertensive rats (SHR), as well as their correlation with physiological phenotype of cardiovascular system. Methods Haemodynamic indexes of the cardiovascular system were measured. Heart weight and left ventricular weight were determined to calculate the ratio of heart weight to body mass (HW/BM) as well as left ventricular mass index (LVMI) in both male SHR and Wistar rats. Real-time PCR after RT were performed to determine the level of RGS mRNA in aorta and heart. Results Systolic blood pressure (SBP) of SHR was significantly higher than that of the control (229?29 vs. 121?12 mm Hg, P
