Relationship between mutations in the ALOX5AP gene and ischemic stroke
- VernacularTitle:ALOX5AP基因突变与缺血性脑卒中的关系
- Author:
Qiang GAO
;
Chunxiao YANG
;
Luyan MU
- Publication Type:Journal Article
- Keywords:
ALOX5AP;
ischemic stroke;
gene
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the mutations in the ALOX5AP gene and ischemic stroke.Methods In 26 patients with acute cerebral infarction and 23 normal controls,the mononucleoside polymorphism(SNPs)in the ALOX5AP was analysised by the single strand conformation polymorphism analysis of polymerase chain reaction products(PCR-SSCP)and Sanger's dideoxy chain termination.Results The frequency of SG13S100(A/G)in the ALOX5AP gene in group of cerebrall infarction(18/26,69.2%)was significantly higher than that in normal controls(8/23,34.8%)(P
