Changes and its significance of expression of platelet CD62p,CD42b and the levels of plasma TXB_2,6-keto-PGFla and vWF in patients with intracerebral hemorrhage
- VernacularTitle:脑出血患者血小板CD62p、CD42b表达及血浆血栓素B_2、6-酮前列腺素-F1a和血管性假血友病因子水平的变化及其意义
- Author:
Xiangdong GAO
;
Qingxin LIU
;
Xiaohua JIN
- Publication Type:Journal Article
- Keywords:
intracerebral hemorrhage;
platelet activation;
vascula endothelium
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and its significance of expression of platelet CD62p,CD42b and the levels of plasma TXB2,6-keto-PGFla and vWF in patients with intracerebral hemorrhage.Methods 46 patients with intracerebral hemorrhage were included as the intracerebral hemorrhage group,while 20 patients with hypertension were served as the control group.Platelet CD62p and CD42b were measured by flow cytometry,and plasma TXB2,6-keto-PGF1a and vWF were measured by ELISA at less than 3 day,1 and 2 weeks after onset.The analysis of dependablit were made between the expression of platelet CD62p,CD42b and the level of plasma vWF in patients with intracerebral hemorrhage.Results At less than 3 day,1 and 2 weeks after onset,the expression of platelet CD62p,levels of plasma TXB2,vWF and TXB2/6-keto-PGFla(T/K)in patients with intracerebral hemorrhage were significantly higher than those in the control group(all P
