Effects of Melatonin on cognition and tau hyperphosphorylation in hippocampus of Alzheimer's disease model rats
- VernacularTitle:褪黑素对Alzheimer病模型大鼠认知功能和海马tau蛋白过度磷酸化的影响
- Author:
Min WANG
;
Feng ZHANG
;
Xiaohong LI
- Publication Type:Journal Article
- Keywords:
Melatonin;
Alzheimer's disease;
cognition;
tau;
phosphorylation
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To sdudy the effects of Melatonin(MT)on cognition and tau hyperphosphorylation in hippocampus of Alzheimer's disease(AD)model rats.Methods A?25-35 was injected into the hippocampus to make AD model rat.MT was injected intraperitoneully into rats of MT group 7 days before and 19 days after modeling.Normal saline(NS)was injected intraperitoneully into rats of AD group after modeling.The cognition was tested by Morris water maze.The pathological changes of hippocampus was observed by Bielschowsky staining and the tau hyperphosphorylation was detected by immunohistochemistry staining.The results were compared with normal control group.Results In MT group,the results of Morris water maze were significant better than those in AD group(all P
