Infection among Renal Transplant Recipients Using Two Dfferent Immunosuppressive Schemes:A Comparitive Study
- VernacularTitle:两种免疫抑制方案肾移植患者感染的调查
- Author:
Ping JIA
;
Xiaoli WU
;
Jingen JIANG
- Publication Type:Journal Article
- Keywords:
Mycophenolate mofetil;
Azathioprine;
Renal transplantation;
Infection
- From:
Chinese Journal of Nosocomiology
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To compare mycophenolate mofetil(MMF) with azathioprine(AZA) addition to ciclosporin-prednisone protocol after kidney transplantation in aspect of infections,and to study the etiology of pulmonary infection and urinary tract infection in the two groups.METHODS Totally 249 patients with kidney transplantation were analyzed retrospectively.These patients were divided into two groups according to the immunosuppressive regimen: AZA group(89 patients),and MMF group(160 patients).The various infectious complications were analyzed during a 1-year follow-up,and the etiology of pulmonary infection and urinary tract infection was studied in the two groups.RESULTS The total incidence of the infections,the incidences of the pulmonary infection,urinary tract infecion,wound infection,and so on,during a 1-year follow-up,were equivalent between the two groups.But the incidence of ARDS and the mortality of patients with lung infection was significantly different.The etiology of pulmonary infection was different between the two groups.Cytomegalovirous and fungal infections were higher in MMF group than those in AZA group.Also the etiology of urinary tract infection was different,the incidences of Gram-positive bacterial and fungal infections were higher in MMF group than those in AZA group.CONCLUSIONS Comparing with AZA,MMF increased the opportunity of serious lung infection.The incidences of opportunistic infection and fungal and viral infections increased obviously in MMF group.So therapy should be individualized and aimed.
