Immunoregulation effects of polysaccharides isolated from Octopus dollfusi on immunosuppression mice
- VernacularTitle:弯斑蛸多糖对免疫抑制小鼠的调节作用
- Author:
Xiaoling LEI
;
Shujin ZHAO
;
Linlan JIANG
- Publication Type:Journal Article
- Keywords:
polysaccharide from Octopus dollfusi;
immunosuppression;
index of immune organs;
white blood cell
- From:
Chinese Journal of Marine Drugs
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the immunoregulation effect of three kinds of polysaccharides extracted from different tissues of Octopus dollfusi on immunosuppression mice.Methods Two kinds of immunosuppression mice models were built by ip,cyclophosphamide(CY) and sc.hydrocortisone(HC),respectively.The spleen and thymus were weighed and the index of the immune organs was calculated.The white blood cells were counted by automated hematologic analyzer.Results In certain concentrations(20～80 mg?kg-1),the three kinds of polysaccharides could antagonize the atrophy of spleen and thymus caused by CY and HC,and increase the weight of spleen and thymus;The polysaccharides could protect against leukocytopenia induced by CY and HC,and especially in low and middle dose.Conclusion The results suggested that three kinds of polysaccharides extracted from Octopus dollfusi have potent enhancement effect on non-specific immunity for the immunosuppression mice.
