Comparative study on immunoregulation of sulfated propylene glycol alginate and its fractions
- VernacularTitle:藻酸双酯钠及其分级产物免疫调节作用比较研究
- Author:
Changzheng LIN
;
Huashi GUAN
;
Guangli YU
;
Haihua LI
;
Caixia GU
- Publication Type:Journal Article
- Keywords:
sulfated propylene glycol alginate;
polysaccharides;
molecular weight;
immunoregulation
- From:
Chinese Journal of Marine Drugs
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of sulfated propylene glycol alginate(PSS) and its fractions on the immunoregulation.Methods The immunoregulation activity of PSS and its fractions were investigated by using immunocyte cultivation technique in vitro.The structure activity relationship was analysed on the basis of the structure studies of PSS' fractions.Results The experimental results showed that PSS could improve spleen cell proliferation,enhance macrophage phagocytic function and inhibit T-cell and B-cell proliferation.Conclusion PSS possessed significant immunoregulation effect,whilst the immunocompetence comparison of PSS' fractions proved that the different immunocytes had different requirements for saccharides length.
