Alteration of Plasma Neuropeptide Y in Patients with Essential Hypertension
- VernacularTitle:原发性高血压患者血浆神经肽Y的变化
- Author:
Rumin ZHANG
;
Mei GAO
;
Zheng ZHANG
;
Shifu WANG
;
Li JIANG
;
Huaiquan WANG
;
Bin ZHU
- Publication Type:Journal Article
- Keywords:
Essential hypertension;
Neuropeptide Y;
Physiopathologic proceeding;
Target organ damage
- From:
Chinese Journal of Hypertension
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the change of plasma neuropeptide Y(NPY) concentration in patients with essential hypertension,and its relevance to target organ damage.Methods The plasma NPY concentration was determined by radioimmunoassay(RIA) in 115 patients with essential hypertension,including 45 patients with single target damage(left ventricle hypertrophy 21,stroke 13,nephropathy 11) and 19 patients with multiple target damage,with 30 normal as controls.Results 1) Plasma NPY concentration in patients with essential hypertension was significantly higher than normal controls(P0.05).Conclusion NPY may involve in the physiopathologic progress of essential hypertension and associate with the development of target organ damage.Evaluation of plasma NPY concentration may be valuable biomarker in estimation the severity of hypertension and target organ damage.
