Expressions of NMDAR2 and GLAST in supraoptic nucleus and hippocampal gyrus under sleep deprivation in young rats
- VernacularTitle:睡眠剥夺应激对幼鼠海马和视上核中谷氨酸受体及转运体表达的影响
- Author:
Shengzhi WANG
;
Jingjie WANG
;
Qingjiu MA
;
Xianli HE
;
Jing NAN
;
Yunxia QIN
;
Jianyong QIU
- Publication Type:Journal Article
- Keywords:
Sleep deprivation;
Hippocampal gyrus;
Supraoptic nucleus;
NMDAR2;
GLAST
- From:
Journal of Medical Postgraduates
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the expressions of NMDAR2 and GLAST in the hippocampal gyrus and supraoptic nucleus(SON) under sleep deprivation in young rats.Methods: The changes in expressions of NMDAR2 and GLAST in SON and hippocampal gyrus under sleep deprivation in younger rats were observed by immunohistochemistry method. Results:The expressions of NMDAR2 and GLAST in SON and the hippocampal gyrus were significantly increased on the 3rd day of sleep deprivation,even more sigificantly on the 5th day,decreased gradually on 7th day,and became similar to those of control group on the 14th day.Conclusion: Sleep deprivation can affect the expressions of NMDAR2 and GLAST in the hippocampal gyrus and supraoptic nucleus,but the effect diminisshes gradually with prolonged time,which may be associated with self-regulation and self-protection of the central nervous system.
