Advance in The Neural Adhesion Molecule CHL1 in Nervous System
- VernacularTitle:神经粘附分子CHL1在神经系统中的研究进展
- Author:
Xin HUANG
;
Lingling ZHU
;
Ming FAN
- Publication Type:Journal Article
- Keywords:
immunoglobulin superfamily,neural adhesion molecule CHL1,nervous system
- From:
Progress in Biochemistry and Biophysics
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Cell adhesion molecules(CAMs) play important roles in specifying cell-cell interactions during development,regeneration,and modification of synaptic activity.The close homolog of L1(CHL1) ,a recently identified member of the immunoglobulin superfamily of cell adhesion molecules,is localizably expressed in the nervous system.CHL1 interacts with like molecules(homophilic interaction) and non-like molecules(heterophilic interaction) on neighboring cells or the extracellular matrix to regulate axon outgrowth and fasciculation,neuronal migration and survival,synaptic plasticity and regeneration after trauma.
