Significance of c-erbB-2 protein expression on the prognosis of gastric carcinoma:a Meta-analysis
- VernacularTitle:c-erbB-2蛋白表达在胃癌预后中的Meta分析
- Author:
Guiping QIN
;
Xian LU
;
Guangqiang QI
;
Chengyi QU
;
Jianfang LIANG
;
Shiying LI
- Publication Type:Journal Article
- Keywords:
gastric carcinoma;
prognosis;
c-erbB-2;
Meta analysis
- From:
Basic & Clinical Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association of c-erbB-2 protein expression with the prognosis of gastric carcinoma. Methods Eleven literatures were analyzed which published in recent 15 years on the relationship of c-erbB-2 with prognosis quantitively by software RevMan. Results The pooled odds ratio(OR) of 5-year survival rates was 0.69(95% CI:0.54～0.87)for all 11 literatures. The pooled odds ratio(OR) of three literatures from eleven literatures was 0.67(95%CI:0.48～0.94)which 5-year survival rates was determined as final index and OR as associated.For well-differentiated and advanced gastric carcinoma, the pooled odds ratio(OR) of 5～year survival rates were 0.18(95%CI:0.09～0.38)and 0.72(95%CI:0.47～1.09)respectively.Conclusion The association of c-erbB-2 expression with prognosis of gastric carcinoma is negative.
