Apoptosis in the gastric mucosa with stress induced damage
- VernacularTitle:大鼠应激性胃黏膜损伤时细胞发生凋亡
- Author:
Jing LIU
;
Zhaoshen LI
- Publication Type:Journal Article
- Keywords:
stress;
gastric mucosa injury;
apoptosis;
BCL-2;
BAX
- From:
Basic & Clinical Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of the gastric epithelial cell death with stress induced damage. Methods Water immersion-restraint stress model was developed with SD rats, Apoptotic cells were quantitated in gastric mucosa by terminal deoxynucleatidyl transferase mediared dUTP nick and labelling (TUNEL) techniques and electronmicroscopy while the BCl-2/BAX proteins were detected by immunohistochemical staining. Results Comparing with the control groupe, at 2 h after the WRS, the mucosa seriously damaged, the apoptotic quantities rose significantly(P
