Comparative study between bone marrow cell transplantation and Ad_5-HGF transfer via noninfarct-relative artery on neovascularization and heart function after myocardial infarction in swine
- VernacularTitle:骨髓间充质干细胞移植与肝细胞生长因子转导对猪心肌梗死后心力衰竭治疗作用的比较
- Author:
Liansheng WANG
;
Wei WANG
;
Zhijian YANG
- Publication Type:Journal Article
- Keywords:
Mesenchymal stem cells transplantation;
Vascular endothelial growth factor;
Myocardial infarction;
Congestive heart failure
- From:
Chinese Journal of Interventional Cardiology
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
50%.Myocardial infarction(MI) models were created by ligating the distal left anterior descending artery in swines(n=18).Either BM-MSCs cells(5?106/mL)(n=6) or Ad5-HGF(4?109 pfu)(n=6) were transfused into infracted area via noninfarction-related artery at four weeks after MI.IMDM fluid was injected into the noninfarction-related artery in the control(n=6).Gate cardiac perfusion imaging was performed at four and seven weeks after LAD ligation respectively to evaluate the heart function and cardiac perfusion.Morphologic and histologic characteristics of the hearts were also studied.Results(1) New vessels firnation was found around the infarction area in all the three groups.By means of immno-histological staining,the density of capillaries and vessels with function in the BM-MSCs group and the Ad5-HGF group were 102.4?8.6/mm2 and 105.3?7.7/mm2,as well as 52.1?4.1/mm2 and 66.0?3.3/mm2 respectively.Both vessel density were higher than those of the control(55.5?4.7/mm2 and 16.4?3.5/mm2,P
