The influence of ABCB1 and OPRM1 genetic polymorphism on fentanyl requirements for postoperative pain control.
10.4097/kjae.2008.55.3.332
- Author:
Chang Shin PARK
1
;
Hye Jin PARK
;
Young Deog CHA
;
Ju Hee KANG
;
Ju Youn CHOI
;
So Jin PARK
;
In Jun CHUNG
Author Information
1. Department of Pharmacology, College of Medicine, Inha University, Incheon, Korea.
- Publication Type:Original Article
- Keywords:
fentanyl;
genetic polymorphism;
pharmacodynamics;
pharmacogenetics
- MeSH:
Analgesia, Patient-Controlled;
Analgesics, Opioid;
Anesthesia;
Blood-Brain Barrier;
DNA;
Fentanyl;
Humans;
Leukocytes;
P-Glycoprotein;
Pain, Postoperative;
Pharmacogenetics;
Polymorphism, Genetic
- From:Korean Journal of Anesthesiology
2008;55(3):332-337
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Fentanyl, which is a potent synthetic micron-opioid receptor agonist, is one of the most widely used opioids in anesthesia and pain control. However, the pharmacodynamics of fentanyl show wide inter-individual variability. Therefore, this study was conducted to evaluate the influence of the blood-brain barrier transporter protein, p-glycoprotein, and micron-opioid receptor genetic polymorphism on fentanyl pharmacodynamics. METHODS: Seventy-nine patients who underwent posterior lumbar interbody fusion (PLIF) were included in this study. Postoperatively, the patients received fentanyl via an intravenous patient controlled analgesia device. The cumulative fentanyl doses and other pharmacodynamic data were then recorded at 2 h, 6 h, 12 h, 24 h and 48 h after the operation. In addition, genomic DNA was isolated from the patient's peripheral leukocytes and then evaluated for the presence of OPRM1 A118G and ABCB1 C3435T genetic polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: The results of this study indicated that ABCB1 C3435T genetic polymorphism may be related to the cumulative fentanyl requirement for postoperative pain control. However, these findings were not statistically significant (P = 0.09). In addition, no relationship was observed between OPRM1 A118G and the cumulative postoperative fentanyl requirement. However, the cumulative postoperative fentanyl requirement was lower in the TTAA group (ABCB1 3435 TT, OPRM1 118 AA) than in the CCGG group (ABCB13435 CC, OPRM1 118 GG). CONCLUSIONS: The ABCB1 C3435T polymorphism may affect fentanyl pharmacodynamics. However, further studies are required to confirm the relationship between p-glycoprotein and fentanyl.
