Rapid eye movement sleep behavior disorder as a predicting phenomenon of ?-synucleinopathies(report of 1 case)
- VernacularTitle:?-触核蛋白病的前驱征——快速眼动期睡眠行为障碍(附1例报告)
- Author:
Yingdong ZHANG
;
Jie LU
;
Jingping SHI
- Publication Type:Journal Article
- Keywords:
rapid eye movement sleep behavioral disorder;
?-synucleinopathy;
neurodegenerative disease
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve the recognition of rapid eye movement(REM) sleep behavior disorder(RBD) as an early marker for ?-synucleinopathies.Methods By studying a typical case of RBD followed with multiple system atrophy-P,the clinical features,pathogenesis and its correlation with ?-synucleinopathies of RBD were elucidated.Results This case manifested a serial of paroxysmal increased activities of the limbs and behavioral disturbances during his REM sleep,and parkinsonism features appeared 9 years later.His cranial MRI showed the abnormal long T1 and T2 signals at bilateral centrum ovale,corona radiate and basal ganglia area of the cerebral hemisphere.Conclusions RBD is clinically characterized with paroxysmal behavioral disorder in the REM sleep,the changes of the brain stem,striatum and cortical perfusion are attributed to the RBD pathogenesis.Closely linked to a-synucleinopathies,RBD may be clinical harbinger of those disorders.
