The effect of propofol on myocardial protection after regional ischemia-reperfusion injury in an in vivo rat heart model.
10.4097/kjae.2008.55.3.338
- Author:
Il Woo SHIN
1
;
Byeong Won LIM
;
Young Seok CHUNG
;
Hyo Min LEE
;
Ju Tae SOHN
;
Heon Keun LEE
;
Young Kyun CHUNG
Author Information
1. Department of Anesthesiology and Pain Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea. ykchung@nongae.gsnu.ac.kr
- Publication Type:Original Article
- Keywords:
heart;
in vivo;
ischemia-reperfusion injury;
propofol
- MeSH:
Animals;
Catheters;
Coronary Vessels;
Emulsions;
Heart;
Heart Ventricles;
Hemodynamics;
Ischemia;
Myocardium;
Phospholipids;
Propofol;
Rats;
Reperfusion;
Reperfusion Injury;
Salicylamides;
Soybean Oil;
Tetrazolium Salts;
Ventricular Pressure
- From:Korean Journal of Anesthesiology
2008;55(3):338-343
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: It is known that propofol protects myocardium against a global ischemia-reperfusion injury in the isolated rat heart model. The aim of this study was to investigate whether propofol, at a clinically relevant concentration infused during the peri-ischemic period, also provides a protective effect against a regional myocardial ischemia-reperfusion injury in vivo. METHODS: Rats were subjected to 25 minutes of coronary artery occlusion followed by 24 hours of reperfusion. Propofol or intralipid was administrated during 35 minutes starting 5 minutes before the onset of ischemia until 5 minutes after the onset of reperfusion. A micromanometer catheter was advanced into the left ventricle and the hemodynamic function was evaluated. The infarct size was determined by triphenyltetrazolium staining after 24 hours of reperfusion. RESULTS: Propofol administration during the peri-ischemic period demonstrated protective effects on hemodynamic function and infarct size reduction. In the control group, the peak rate of the ventricular pressure increase (+dP/dt(max))(P = 0.0001) and the peak rate of the intraventricular pressure decline (-dP/dt(max))(P = 0.0001) were significantly decreased compared to the sham group. In the propofol group, the +dP/dt(max) (P = 0.003) and -dP/dt(max) (P = 0.002) were significantly improved compared to the control group. The infarct size was 47.6% of the area at risks in the control group, and was reduced markedly by administration of propofol during the peri-ischemic period to 26.2% in the propofol group (P = 0.004). CONCLUSIONS: Propofol, at a clinically relevant concentration infused during the peri-ischemic period, have protective effect after regional myocardial ischemia-reperfusion injury in an in vivo rat heart model.
