Comparative study of Topiramate and Sodium Valproate as prophylactic therapy for migraine
- VernacularTitle:托吡酯和丙戊酸钠预防偏头痛发作的对比研究
- Author:
Kaiyun ZHU
;
Yan HUANG
;
Yunxin HU
- Publication Type:Journal Article
- Keywords:
Topiramate;
Sodium Valproate;
migraine
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy,safety,and tolerability of Topiramate(TPM) and Sodium Valproate(SV) as prophylactic therapy for migraine.Methods Prospectively,total of 146 patients with episodic migraine were randomly divided into two groups:TPM group(74 cases) and SV group(72 cases).TPM was titrated by 25 mg per week for 2～4 weeks and the highest dose was 100 mg/d.SV was given at 200 mg twice daily during initial titration of therapy and the highest dose was 600 mg/d.The therapies lasted for 13 weeks,meanwhile the migrain frequency,days and the severity of headache were recorded in headache diaries.The severity of headache was rated on a 0～10 rating scale.Results Mean frequency of headache attack decreased from 7.01 to 1.89 times per month(P
