Effect of glial cell line-derived neurotrophic factor on the expressing of calbindin D28K in substantia nigra of rat model of Parkinson's disease
- VernacularTitle:胶质细胞系源性神经营养因子对帕金森病大鼠黑质钙结合蛋白表达的影响
- Author:
Chenghua XIAO
;
Hua YANG
;
Dianshuai GAO
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
dopaminergic neuron;
glial cell line-derived neurotrophic factor;
calbindin;
neural cell adhesion molecule
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of glial cell line-derived neurotrophic factor(GDNF) on the expressing of calbindin D28K(CB) in substantia nigra(SN) of rat model of Parkinson's disease(PD) and the possible role of neural cell adhesion molecule(NCAM) in this course.Methods 36 rat models of PD were made,and divided into GDNF group,NCAM blocked group and control group(each group had 12 rats).Immunohistochemistry and Western blot method were used to detect the number of CB-positive cells and the expressed level of CB protein in SN of rats.Results The number of CB-positive cells(46.50?6.28) and the expressed level of CB protein(33770.60?6929.76) in SN of GDNF group were significantly higher than control group [(27.00?8.60),(18281.00?5266.78) respectively](all P0.05).Conclusions GDNF may protect the injured dopaminergic neurons through up regulating the expressing of CB,but NCAM is not involved in this mechanism.
