Expressing changes of nitric oxide synthase in substantia nigra and striatum of hemiparkinsonism monkey model
- VernacularTitle:偏侧帕金森病猴模型黑质和纹状体一氧化氮合酶表达的变化
- Author:
Haidong HUANG
;
Jianwen GU
;
Kai ZHAO
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
nitric oxide synthase;
substantia nigra;
striatum
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressing changes of nitric oxide synthase(NOS) in substantia nigra and striatum of the hemiparkinsonism monkey model.Methods Three hemiparkinsonian rhesus monkey models were induced by injecting 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) unilaterally into the internal carotid artery.The expressing changes of NOS-positive neurons of substantia nigra and striatum in three hemiparkinsonism monkey models and one normal control monkey were observed by using NADPH-diaphorase histochemistry staining method.Results The NOS-positive neurons were increased significantly in the substantia nigra and striatum of MPTP lesioned side of hemiparkinsonian monkey model compared to contralateral side and normal control monkey(all P
