Effect of Valsartan on oxidative stress in brain tissue of diabetic rats
- VernacularTitle:缬沙坦对糖尿病大鼠脑组织氧化应激的影响
- Author:
Tingting ZHAO
;
Xueping LIU
;
Bing CHEN
- Publication Type:Journal Article
- Keywords:
Valsartan;
diabetes;
oxidative stress
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Valsartan on oxidative stress in brain tissue of diabetic rats.Methods Diabetic Wistar rats were induced by streptozotocin(STZ) and were randomly divided into diabetic group and Valsartan treatment group.In Valsartan treatment group,the rarts received Valsartan 40 mg/(kg?d) for 12 weeks by intragastric administration.Then blood glucose and body weight were measured.The cognition ability of rats was assayed with Morris water maze test.The activities of superoxide dismutase(SOD),maleic dialdehyde(MDA) and hydroxy radical(OH-) were detected by chromatometry.Quantitative real-time RT-PCR was performed to detect the expression of NADPH oxidase p47phox mRNA.Results(1) Compared with normal control group,the body weight in diabetic group and Valsartan treatment group decreased significantly(both P
