Effects of Nimodipine on the c-fos and c-jun mRNA expressions in dorsal root ganglia of rate following acute injury
- VernacularTitle:尼莫地平对急性损伤后大鼠背根节细胞c-fos、c-jun mRNA表达的影响
- Author:
Xu YAO
;
Xinsheng DING
;
Jinrong TANG
- Publication Type:Journal Article
- Keywords:
Nimodipine;
c-fos;
c-jun;
neuroprotective effect
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of Nimodipine on oncogene c-fos and c-jun mRNA expressions in dorsal root ganglia of rats following acute sciatic nerve injury.Methods Nimodipine at a dose of 10 mg/kg at 5,15,30,60 and 120 min and at a different dose of 2.5,5 and 10 mg/kg at 60 min was given to each rat through intraperitoneal injection before transection of sciatic nerve.Using reverse transcription PCR(RT-PCR) technique,the c-fos and c-jun mRNA expressions were detected at 5,15,30,60 and 120 min after injection of Nimodipine and following acute sciatic nerve injury.Results Compared with control group,the expressions of c-fos mRNA in injury group were obviously increased at 30,60 and 120 min after injury(all P
