Value of magnetic resonance angiography-diffusion mismatch to predict the ischemic penumbra in acute ischemic stroke
- VernacularTitle:磁共振血管成像-弥散成像不匹配对预测急性缺血性脑卒中缺血半暗带的价值
- Author:
Xiaoling LIAO
;
Yilong WANG
;
Yongjun WANG
- Publication Type:Journal Article
- Keywords:
acute ischemic stroke;
ischemic penumbra;
magnetic resonance angiography;
diffusion-weighted imaging
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of magnetic resonance angiography-diffusion mismatch to predict the ischemic penumbra in acute ischemic stroke.Methods Patients with acute cerebral infarcts within the middle cerebral artery territory and imaged within 6 hours after symptom onset were prospectively studied.MRI including MRA,DWI and PWI sequences were performed on admission.We defined MRA-DWI Volume mismatch as MCA(M1) occlusion and DWI lesion volume≤25 ml.MRA-DWI ASPECTS mismatch was defined as MCA(M1) occlusion and Alberta Stroke Program Early CT Score of DWI≥7.DWI lesion and PWI(MTT) volumes were measured by planimetric techniques.PWI-DWI mismatch was examined as a categorical variable(mismatch=PWI-DWI/DWI?100%≥20%).Results 78 patients met inclusion criterion,MRA-DWI Volume mismatch detected PWI-DWI mismatch with a specificity of 100%,but a sensitivity of only 46%.MRA-DWI ASPECTS mismatch detected PWI-DWI mismatch still with a high specificity of 100% and a low sensitivity of only 42.9%.Conclusions MRA-DWIVolume mismatch and MRA-DWI ASPECTS mismatch predict the presence of PWI-DWI mismatch with high specificity and low sensitivity.They may be useful to select patient candidates for thrombolysis.
