Influence of gene polymorphism on response of sulphonylurea
- VernacularTitle:基因多态性对磺脲类降糖药物反应的影响
- Author:
Lili CHEN
;
Qiang LI
- Publication Type:Journal Article
- Keywords:
Sulphonylurea;
Sulphonylurea receptor1 genes;
Inwardly rectifying K+ channels 6.2 genes
- From:
Journal of Medical Postgraduates
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
To explore the relation between the gene polymorphism of type 2 diabetes patients and their response to sulphonylurea(SU) and accomplish the personal therapy,the range of the SU pharmacogenomics should includes genes involved in the process of SU metabolism and acting,other pathological or physiological process of type 2diabetes also should be investigated,the genes recoding sulphonylurea receptor 1(SUR1),inwardly rectifying K+ channels 6.2(Kir6.2),CYP2C9 and insulin receptor substrate 1(IRS1) are the most important.
