Healing mechanism of intestinal anastomosis in intra-abdominal sepsis rats
- VernacularTitle:腹腔感染对肠吻合口愈合影响机制的研究
- Author:
Yang BAO
;
Yousheng LI
;
Jie MA
;
Guiqin SUN
;
Jieshou LI
- Publication Type:Journal Article
- Keywords:
Intra-abdominal sepsis;
Wound healing,mechanism
- From:
Journal of Medical Postgraduates
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the mechanism of intestinal anastomosis in a rat model of intra-abdominal sepsis.Methods:Male Wistar rats were randomized into 2 groups.Control rats underwent intestinal anastomosis.Sepsis group underwent intestinal anastomosis after intestinal fistula operation.fibronectin(FN),?-smooth muscle actin(?-SMA),vascular endorthelial growth factor(VEGF) and apoqtosis in anastomoses were measured.Results:FN,?-SMA,VEGF in control group were higher than sepsis group and apoptosis were lower than the other.Conclusion:It is indicated that the repair of tissue was out of balance after infection,and the organization repair was retarded.The collagenoblast and the epithelial cell migration were slowed down,and the blood capillary regeneration was slowly.Not only the granulation organization was reduced,but also apoptosis was prematurely appeared.
