Clinicopathological features of solid-pseudopapillary neoplasm of the pancreas
- VernacularTitle:胰腺实性-假乳头状瘤临床病理特征
- Author:
Jinjun SONG
;
Xiaojun ZHOU
;
Zhenfeng LU
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasm;
Immunohistochemistry;
Diagnosis
- From:
Journal of Medical Postgraduates
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinical and pathological features of solid-pseudopapillary neoplasm of pancreas with emphasis on its diagnosis and differential diagnosis.Methods:Clinical data,pathological features and immunohistochemical findings were collected and a review of the literature was made,differential diagnosis was discussed in the cases of SPNP. Results:All the 5 patients were females,age from 16 to 65 years(average 32 years),there were no recurrence after tumor resection.The mean diameter of tumors was 8 cm,all encapsulated,and solid with cystic changes.Histological examination showed presence of solid sheets,Psudopapillary with uniform population of cells.The nuclei were oval,round without atypia,and mitotic figures were rare.Psudopapillary structure with fibrovascular core was remarkable.Hemorrhage,foamy cells and cholesterol crystals were often found.Immunohistochemically,5 cases were positive for ?1-ACT and Vimentin,3 cases expressed NSE and Syn,2 cases expressed CgA and CK.All cases were negative for Insulin and EMA.Conclusion:SPNP is a rare pancreatic neoplasm.Histologically,uniform population of cells formed psudopapillary structure with a fibrovascular core,and it is a clinicopathologic entity in young female patients with a benign clinical course.
