Identification of a novel HLA class Ⅰ allele,B~*1316
- VernacularTitle:序列分析鉴定新等位基因HLA-B~*1316
- Author:
Xiaomei HE
;
Xiaoyan SHAN
;
Zhixin ZHANG
- Publication Type:Journal Article
- Keywords:
HLA-B*1316;
Novel allele;
HLA;
PCR-SSO;
SBT
- From:
Chinese Journal of Blood Transfusion
1988;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the nucleotide sequences of novel HLA class I le,B*1316.Methods Routine sequence-specific oligonucleotide(SSO) typing and sequencing based typing(SBT) was used.Results The B*1316 allele differs from B*1302 by one nucleotide substitution in exon 3: T to A at nt position 184,which results in an amino acid substitution at codon 62 from Val to Glu.Conclusion A novel HLA class I allele,B*1316 has been identified,and was officially recognized by WHO Nomenclature Committee in April 2006.
