A new stent for accelerating recovery of vascular endothelium:Endothelial cells or endothelial progenitor cells seeded stent and in-stent restenosis
- VernacularTitle:加速血管内皮修复功能的新型支架:内皮细胞或内皮先祖细胞种植支架与支架后再狭窄(英文)
- Author:
Guangfu WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(33):-
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:In order to decrease restenosis after percutaneous transluminal coronary angioplasty(PTCA)or percutaneous coronary intervention(PCI),cell implantation stent attracts more and more attention in application and researches during recent years.This study is designed to review the studies on relationship between in-stent restenosis prevention and cell-seeded stent in recent years.DATA SOURCES:A computer-based online search of MUBMED database was undertaken to identify articles about the restenosis after stent operation of vascular endothelium published in English between January 1990 to December 2006,and the were endothelial cell,seed,restenosis.Meanwhile,Chinese relevant articles published between January 1990 to December 2006 were searched in CNKI database with the keywords of "endothelial cell,implantation,stent,restenosis" in Chinese. STUDY SELECTION:Initially,the studies without control group and with repeated content were excluded.Remained literatures mainly concerning endothelial cell seeding and accelerating vascular reendothelialization were retrieved in full text. DATA EXTRACTION:Thirty-one articles mostly relating with the topic of the present review were selected among those literatures. DATA SYNTHESIS:① Restenosis is the key problem among the long term side effect of percutanious coronary intervention.② There is a considerable relationship between integrity of vascular endothelium and intima hyperplasia and in-stent restenosis.In modulating structure remodeling of injuried intima the endothelium functions importantly and,promotes integrity restoration to inhibit intima hyperplasia.Therefore,study on accelerating reendohthelialization becomes hot topic at present.③ There are two ways to promote repair of injured endothelium.One is local delivery of relative gene or drug infusion,and the other is locally direct seeding of vascular endothelial cells.④ Besides two main methods used to improve endothelium restoration,another newly method in which the endothelial cells seeded on stent locally proliferate and rapidly recover the stent and trauma intima is becoming a hot study poiont recently.Along with advance of research on endothelial progenitor cells,it may become a kind of ideal source for seeding. CONCLUSION:With the improvement of bioengineering stent manufacture technics,as one of anti-restenosis strategies,a newly endothelial cells(ECs)-or endothelial progenitor cells(EPCs)-seeded stent possessing a function of accelerating endothelium recover would have an important station in the field of coronary heart disease intervention therapy.
