Effects of orphanin FQ on somatosensory evoked potential and Na~+-K~+A TPase activity in cerebral cortex of rats
- VernacularTitle:孤啡肽对大鼠皮层体感诱发电位和Na~+-K~+ ATP酶活性的影响
- Author:
Shuwei JIA
;
Yurong LI
;
Lihui QU
;
Xianghui ZOU
;
Hui ZHANG
- Publication Type:Journal Article
- Keywords:
orphanin FQ;
morphine;
somatosensory evoked potential (SEP);
Na~+-K~+ATPase
- From:
Basic & Clinical Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of intracerebroventricular injection of morphine and orphanin FQ (OFQ) on somatosensory evoked potential (SEP) and Na+-K+ATPase activity in cerebral cortex of rat. MethodsTo study the SEP with the BL-420 biological signal collecting system. The cerebral cortex tissues were extracted, homogenized and centrifuged. Na+-K+ATPase activity was measured with ATPase analytical kit. Results After intracerebroventricular injection with OFQ 0.9 ?g, the amplitude of P1-N1 and N1-P2 increased significantly(P
