Role of MAP kinase cascades in pain modulation
- VernacularTitle:丝裂原活化蛋白激酶在疼痛信号调制中的作用
- Author:
Ying LU
;
Li ZHU
;
Yongjing GAO
- Publication Type:Journal Article
- Keywords:
mitogen-activated protein kinases;
pain;
central sensitization;
neuronal plasticity
- From:
Basic & Clinical Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Mitogen-activated protein kinases (MAPKs) are important kinases involved in the intracellular signaling transduction in mammalian. There are three major MAPK pathways: ERK/MAPK,JNK/SAPK and P38 MAPK. Current studies indicate that all of them play significant roles in the processing of pain especially in the development and maintenance of pathological pain. This review will focus on in the study of MAPK in pain modulation. The further insights into its mechanisms may highlight a nice prospect for the therapies of painful diseases.
